Aging Skin & Wrinkles

Skin aging is driven by two processes working simultaneously. Intrinsic aging is genetically programmed: collagen production decreases by roughly 1% per year after age 20, elastin fibers degrade, and cellular turnover slows. By age 50, you have lost approximately 30% of your dermal collagen, leading to thinner skin, fine lines, and reduced elasticity. Extrinsic aging, primarily from UV exposure but also from pollution, smoking, and oxidative stress, accelerates this process by damaging DNA, breaking down collagen fibers, and creating the hyperpigmentation and deep wrinkles associated with photoaging.

The visible signs of aging, wrinkles, sagging, uneven tone, dullness, and loss of volume, reflect structural changes happening at the cellular level. Fibroblasts, the cells responsible for producing collagen and elastin, become less active. Glycosaminoglycans that hold moisture in the dermal matrix decline. The skin barrier weakens, leading to increased transepidermal water loss and sensitivity. These are not cosmetic concerns alone. They represent measurable biological changes.

Over-the-counter serums and moisturizers can improve surface hydration and provide mild antioxidant protection, but they cannot reverse structural collagen loss or increase cellular turnover rate. That requires prescription-grade active ingredients that penetrate the epidermis and influence the behavior of dermal cells directly.

INA's skin aging protocols combine prescription-grade topicals with injectable therapies for comprehensive treatment. Tretinoin, the gold standard of anti-aging dermatology, increases collagen production, accelerates cellular turnover, and reduces fine lines with decades of clinical evidence behind it. Our custom anti-aging compound pairs active ingredients for a targeted approach to your specific concerns. Collagen peptide injections and NAD+ therapy work from within to support the structural proteins and cellular energy that keep skin resilient.

Glutathione injections address oxidative damage and improve skin luminosity from the inside out, while our Skin Radiance Kit provides a complete system for patients who want a comprehensive approach. Your INA physician will evaluate your skin concerns, medical history, and current routine to prescribe the combination that addresses your specific aging pattern, whether that is fine lines, loss of firmness, hyperpigmentation, or overall dullness.